Flu News Day, 8/2/2022

Articles featured in August 2nd’s Flu News Day discuss the need for global health equity and updates in combined Influenza and COVID-19 vaccines. Funding opportunities are also featured.

July 2022

The Radical Plan For Vaccine Equity

The World Health Organization’s mRNA vaccine technology transfer hub is a radical attempt to grow vaccine manufacturing capacities in LMICs, but the effort is currently hindered by the modern vaccine ecosystem. This current system relies on the generosity of those in HICs, a strategy which has left millions unprotected and allowed variants to emerge in the COVID-19 pandemic. The mRNA transfer hub aims to better protect the globe through advancing local LMIC vaccine production, but intellectual property laws may inhibit their commercial distribution. Moreover, contracts to buy local vaccines could address the hurdle that these vaccines will inevitably cost more than those produced at greater scale by larger companies. Still, equity demands that these challenges are met, and a successful technology transfer hub could save millions from infectious disease threats. Read more about these challenges and hear from those determined to help the technology transfer hub succeed here.

Read the full article here
July 2022

Rational development of a combined mRNA vaccine against COVID-19 and influenza

A combined influenza and COVID-19 mRNA vaccine, AR-CoV/IAV, has successfully produced protective immune responses in mice after two doses and may provide new evidence for more broadly protective vaccines. AR-CoV/IAV encodes a combination of a hemagglutinin (HA) antigen from H1N1 influenza A virus, termed ARIAV, and the receptor binding domain of the SARS-CoV-2 S protein, called ARCoV. ARIAV, the influenza component, notably elicits HA stalk-specific antibodies, which can protect against a broad range of heterologous/heterosubtypic viruses. Importantly, AR-CoV/IAV protected mice from co-infection of influenza and COVID-19, which is known to result in severe clinical outcomes. To read more about the humoral and antigen-specific cellular immune responses elicited by AR-CoV/IAV in mice, read the research article here.

Read the full article here
July 2022

Universal financing and coverage of vaccines

A new study published July 19th shows the viability of implementing a pay-it-forward approach as a vaccine financing mechanism. After receiving a free vaccination, research participants in Guangdong, China were asked to donate a discretionary sum to help pay for the cost of vaccinating the community member next in line for the vaccine and were also invited to write a small note for this community member. This equitable financing mechanism increased community confidence, increased uptake of the vaccine among priority populations and led to a ‘substantial cost recovery’. Read more about this potential financing mechanism here.

Read the full article here

Funding Opportunities & Announcements

Planning Grant for Global Infectious Disease Research Training Program [Discretionary Grant]                                                                                                         NIH /January 8, 2021 / October 28, 2022                                  Apply Here

NIAID Resource-Related Research Projects [Discretionary Grant]
NIAID / November 22, 2019 / January 7, 2023                       Apply Here

Data Management Coordinating Center for Diagnostic Centers of Excellence [Cooperative Agreement]                                                                        NIH / July 10, 2022 / August 10, 2022                                       Apply Here

Limited Competition: Research Resource for Human Organs and Tissues [Cooperative Agreement]                                                                                             NIH/ December 25, 2021 / September 25, 2022                     Apply Here

USAID/Uganda Health Activity [Discretionary Grant]                               Uganda USAID-Kampala / July 18, 2022 / August 22, 2022 Apply Here

Public Health Intervention Development [Grant]
Medical Research Council / July 15, 2022 / September 15, 2022 Apply Here

Pediatric Disaster Care [Discretionary Grant]                                       Department of Health and Human Services / July 26, 2022 / August 26, 2022                                                                                                                   Apply Here

RNA vaccine platform technologies and vaccine library development against emerging and select endemic infectious diseases Focus Area 2 [Call for Proposal]                                                                                                                    CEPI / January 17, 2022 / December 31, 2022                         Apply Here

Notice of Special Interest: Promoting Vaccine Access, Acceptance and Uptake among Children, Adolescents, Pregnant and Lactating Women, and Persons with Disabilities [Grant]                                                                          NICHD / June 28, 2021 / May 8, 2024                                        Apply Here

Incentive Grants [Grant]                                                                                             APhA / July 27, 2022 / August 31, 2022                                    Apply Here

Vaccines 2022 Young Investigator Award [Prize]                                       Vaccines Journal / Open Now / December 31, 2022           Apply Here